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In the acute phase, symptoms include euphoria, anxiety, paranoia, and psychomotor agitation, which are primarily caused by the short-term overactivation of neurotransmitter systems (McCann et al., 2008)

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nausea, vomiting, diarrhoea, and constipation) are common [3, 5], serious adverse effects (e.g

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(2007) 4:e66